BH3-only proteins: orchestrating cell death.

The article discusses the fundamental impact of the research conducted by Stanley Korsmeyer and his colleagues on programmed cell death. Korsmeyer was able to characterize chromosomal translocation involving bcl-2 in human follicular lymphoma. His legacies are critical for understanding the fundamental biological process of apoptosis. The role of BH3-only proteins in the modulation of PCD is discussed.