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Hemorheological disorders in the microcirculation during septic shock in rats.
- Source :
-
Clinical Hemorheology & Microcirculation . 2006, Vol. 35 Issue 1-2, p223-226. 4p. 3 Graphs. - Publication Year :
- 2006
-
Abstract
- Objectives: The aim of the present study was the experimental analysis of blood rheological disorders in the microcirculation during endotoxic shock. Methods: Experiments were carried out on 30 white laboratory rats of both sexes weighing about 200 g. The experimental animals were divided in two groups: the control group and the group undergoing experimental endotoxic shock. The following specific hemorheological properties were investigated in all animals during the experiments: red blood cells (RBC) aggregability, their deformability and the systemic hematocrit. Results: We found that all the investigated hemorheological parameters appreciably changed underconditions of endotoxic shock. The RBC aggregability index was increased by a mean of 136%. As to the RBC deformability index was found to be decreased by 71%, and the systemic hematocrit lowered by 31%, as compared to the same parameters in the control group. Conclusion: The data obtained provide us with evidence that the hemorheological derangements associated with the development of the heavy microcirculatory disorders during endotoxic shock, are most significant factors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13860291
- Volume :
- 35
- Issue :
- 1-2
- Database :
- Academic Search Index
- Journal :
- Clinical Hemorheology & Microcirculation
- Publication Type :
- Academic Journal
- Accession number :
- 21714440