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HIV-1 Reverse Transcriptase Mutants Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Do Not Adversely Affect DNA Synthesis: Pre-Steady-State and Steady-State Kinetic Studies.
- Source :
-
JAIDS: Journal of Acquired Immune Deficiency Syndromes . 8/1/2006, Vol. 42 Issue 4, p405-411. 7p. 3 Charts, 3 Graphs. - Publication Year :
- 2006
-
Abstract
- The article discusses a study which examines the effects of HIV type 1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitor (NNRTI). The objective of the study was to evaluate the polymerase functions of the NNRTI-resistant reverse transcriptase including K103N, P236L and V106A. The study showed that, the enzyme interactions with nucleotides created no significant effects on the NNRTI-resistance mutations.
- Subjects :
- *AIDS
*DNA synthesis
*ENZYMES
*NUCLEOTIDES
*HIV infections
Subjects
Details
- Language :
- English
- ISSN :
- 15254135
- Volume :
- 42
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- JAIDS: Journal of Acquired Immune Deficiency Syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 21797262
- Full Text :
- https://doi.org/10.1097/01.qai.0000222288.90201.33