Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy.

Authors :: Adams, J. M.
Huang, D. C. S.
Strasser, A.
Willis, S.
Chen, L.
Wei, A.
Van Delft, M.
Fletcher, J. I.
Puthalakath, H.
Kuroda, J.
Michalak, E. M.
Kelly, P. N.
Bouillet, P.
Villunger, A.
O'Reilly, L.
Bath, M. L.
Smith, D. P.
Egle, A.
Harris, A. W.
Hinds, M.
Source :: Cold Spring Harbor Symposia on Quantitative Biology. 2005, Vol. 70, p469-477. 9p. 5 Diagrams, 1 Graph.
Publication Year :: 2005
Abstract: Discusses the role of the Bel-2 protein family in tumorigenesis and chemoresistance. Factions of interacting proteins including BH3-only proteins; Role of BH3-only proteins in transmission of specific death signals; Findings that highlight the therapeutic prospects for targeting the Bcl-2 family with small molecules.