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Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy.
- Source :
-
Cold Spring Harbor Symposia on Quantitative Biology . 2005, Vol. 70, p469-477. 9p. 5 Diagrams, 1 Graph. - Publication Year :
- 2005
-
Abstract
- Discusses the role of the Bel-2 protein family in tumorigenesis and chemoresistance. Factions of interacting proteins including BH3-only proteins; Role of BH3-only proteins in transmission of specific death signals; Findings that highlight the therapeutic prospects for targeting the Bcl-2 family with small molecules.
- Subjects :
- *PROTEINS
*CARCINOGENESIS
*CARCINOGENICITY
*THERAPEUTICS
*MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 00917451
- Volume :
- 70
- Database :
- Academic Search Index
- Journal :
- Cold Spring Harbor Symposia on Quantitative Biology
- Publication Type :
- Academic Journal
- Accession number :
- 21837124
- Full Text :
- https://doi.org/10.1101/sqb.2005.70.009