Back to Search
Start Over
Sophorolipid produced from the new yeast strain Wickerhamiella domercqiae induces apoptosis in H7402 human liver cancer cells.
- Source :
-
Applied Microbiology & Biotechnology . Aug2006, Vol. 72 Issue 1, p52-59. 8p. 2 Color Photographs, 1 Diagram, 2 Charts, 3 Graphs. - Publication Year :
- 2006
-
Abstract
- The effects of sophorolipid on the growth and apoptosis of H7402 human liver cancer cells were investigated. By treatment with sophorolipid, a dose- and time-dependent inhibition of cell proliferation was observed. The cells developed many features of apoptosis, including condensation of chromatin, nuclear fragmentation, and appearance of apoptotic bodies, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling positive cells were stained dark brown. Sophorolipid treatment induced apoptosis in H7402 cells by blocking cell cycle at G1 phase and partly at S phase, activating caspase-3, and increasing Ca2+ concentration in cytoplasm. These findings may suggest a potential use of sophorolipid for liver cancer treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *APOPTOSIS
*LIVER cancer
*CANCER cells
*CELL proliferation
*CELL death
Subjects
Details
- Language :
- English
- ISSN :
- 01757598
- Volume :
- 72
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Applied Microbiology & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 21908923
- Full Text :
- https://doi.org/10.1007/s00253-005-0243-z