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Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
- Source :
-
Cancer Cell . Aug2006, Vol. 10 Issue 2, p99-111. 13p. - Publication Year :
- 2006
-
Abstract
- Summary: Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by the liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is associated with noncancerous hepatic tissues from metastatic HCC patients. This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine shift in the venous metastasis-associated liver microenvironment coincides with elevated expression of macrophage colony-stimulating factor (CSF1). Moreover, a refined 17 gene signature was validated as a superior predictor of HCC venous metastases in an independent cohort, when compared to other clinical prognostic parameters. We suggest that a predominant humoral cytokine profile occurs in the metastatic liver milieu and that a shift toward anti-inflammatory/immune-suppressive responses may promote HCC metastases. [Copyright &y& Elsevier]
- Subjects :
- *LIVER cancer
*METASTASIS
*INFLAMMATION
*MACROPHAGES
*PATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 10
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 21920526
- Full Text :
- https://doi.org/10.1016/j.ccr.2006.06.016