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Regioselective Synthesis of Fluoroalkylated β-Aminophosphorus Derivatives and Aziridines from Phosphorylated Oximes and Nucleophilic Reagents.
- Source :
-
Journal of Organic Chemistry . 8/4/2006, Vol. 71 Issue 16, p6141-6148. 8p. 8 Diagrams, 5 Charts. - Publication Year :
- 2006
-
Abstract
- A simple and efficient stereoselective synthesis of fluoroalkyl substituted aziridine-2-phosphine oxides and -phosphonates by diastereoselective addition of methoxide, imidazole, benzenethiol, and Grignard reagents to functionalized ketoxime-phosphine oxides and -phosphonates is described. Aziridines are used as intermediates for the regioselective synthesis of fluorine containing β-amino phosphine oxides and β-amino phosphonates. Amino phosphorus derivatives can also be obtained from ketoximes derived from phosphine oxides and phosphonates with sodium borohydride. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 71
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21955618
- Full Text :
- https://doi.org/10.1021/jo060865g