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Arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2
- Source :
-
Biochemical & Biophysical Research Communications . Sep2006, Vol. 348 Issue 3, p1075-1081. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of apoptotic stimuli. Here, we report for the first time the pro-apoptosis role of arsenic trioxide (As2O3) in gallbladder carcinoma and identify the contribution of Bcl-2 in the As2O3-induced apoptosis. The treatment of As2O3 in gallbladder carcinoma cells could induce apoptosis in a dose-dependent manner and downregulate the expression of anti-apoptotic protein Bcl-2 at mRNA level. Moreover, Bcl-2 overexpression could protect gallbladder carcinoma cells from As2O3-induced apoptosis, indicating the contribution of Bcl-2 in As2O3-induced apoptosis. Taken together, these results suggest that arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2, which may have important therapeutic implications in gallbladder carcinoma patients. [Copyright &y& Elsevier]
- Subjects :
- *APOPTOSIS
*CELL death
*CANCER patients
*NATIVE element minerals
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 348
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 22008550
- Full Text :
- https://doi.org/10.1016/j.bbrc.2006.07.181