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Combined liquid chromatography–Tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: Preliminary findings
- Source :
-
Molecular Genetics & Metabolism . Sep2006, Vol. 89 Issue 1/2, p185-187. 3p. - Publication Year :
- 2006
-
Abstract
- Abstract: Utilizing combined liquid chromatography–tandem mass spectrometry (LC–MS/MS) as the analytical method, we have demonstrated a ten to sixtyfold excess of lysophosphatidyl choline containing hexacosanoic acid (26:0) in dried blood spots on a filter paper matrix from 25 male patients with X-linked adrenoleukodystrophy and nine patients with peroxisome biogenesis disorders compared to 19 controls. There was no overlap between normal subjects versus affected subjects. [Copyright &y& Elsevier]
- Subjects :
- *PEROXISOMAL disorders
*LIQUID chromatography
*MASS spectrometry
*VITAMIN B complex
Subjects
Details
- Language :
- English
- ISSN :
- 10967192
- Volume :
- 89
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Molecular Genetics & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 22008828
- Full Text :
- https://doi.org/10.1016/j.ymgme.2006.05.001