Metabolic Engineering of Saccharomyces cerevisiae Producing Nicotianamine: Potential for Industrial Biosynthesis of a Novel Antihypertensive Substrate.

Authors :: Wada, Yasuaki
Kobayashi, Takanori
Takahashi, Michiko
Nakanishi, Hiromi
Mori, Satoshi
Nishizawa, Naoko K.
Source :: Bioscience, Biotechnology & Biochemistry. Jun2006, Vol. 70 Issue 6, p1408-1415. 8p. 3 Diagrams, 4 Graphs.
Publication Year :: 2006
Abstract: The article presents a study which aims to produce large amounts of nicotianamine (NA) fermentatively by introducing the Arabidopsis AtNAS2 gene into Saccharomyces cerevisiae strain SCY4. Nicotianamine is synthesized from the trimerization of S-adenosylmethionine by NA synthase. The successful production of NA in Saccharomyces cerevisiae should pave the way for industrial production of this antihypertensive substrate.

Subjects :: *ARABIDOPSIS
*GENES
*SACCHAROMYCES cerevisiae
*ADENOSYLMETHIONINE
*INDUSTRIES

Full Text Access

Tools