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Mouse lines selected for difference in sensitivity to β-CCM also differ in memory processes
- Source :
-
Behavioural Brain Research . Oct2006, Vol. 173 Issue 2, p282-287. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Methyl-β-carboline-3-carboxylate (or β-CCM) is a benzodiazepine receptor ligand with inverse agonist properties. Two strains of mice were selected, one for sensitivity (BS) and one for resistance (BR) to a convulsive dose of β-CCM. These two strains were then shown to differ in several biochemical, pharmacological and behavioral characteristics; specifically BS mice were less anxious than BR mice. The present work provides evidence of differences in the learning abilities of the two strains. Three different learning tasks were used: spatial delayed discrimination on the 4-hole board, a learned choice between a lit and a dark compartment in a T-maze, and place-learning in an 8-arm radial maze. In all three tasks, BS mice had consistently better performance levels than BR mice. [Copyright &y& Elsevier]
- Subjects :
- *MEDICAL genetics
*BIOCHEMICAL genetics
*LEARNING ability
*PSYCHOLOGY of learning
Subjects
Details
- Language :
- English
- ISSN :
- 01664328
- Volume :
- 173
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Behavioural Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 22218406
- Full Text :
- https://doi.org/10.1016/j.bbr.2006.06.036