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The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels
- Source :
-
Toxicology Letters . Mar2005, Vol. 155 Issue 3, p421-426. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: The effects of the mycotoxin lolitrem B on the function of hSlo large conductance calcium-activated potassium channels expressed in HEK293 cells have been investigated using inside-out membrane patches. Lolitrem B potently inhibited hSlo potassium currents activated by depolarising voltage pulses in the presence of 10μM free calcium. At a concentration of 100nM, lolitrem B rapidly and completely inhibited outward potassium currents. The concentration that produced half-maximal inhibition was 3.7nM, indicating a high apparent affinity for hSlo channels. This is the first time that a molecular site of action has been identified for a compound of the lolitrem structural class of indole diterpene and identifies a novel BK channel blocker. [Copyright &y& Elsevier]
- Subjects :
- *MYCOTOXINS
*POTASSIUM channels
*ION channels
*CALCIUM
Subjects
Details
- Language :
- English
- ISSN :
- 03784274
- Volume :
- 155
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Toxicology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 22230207
- Full Text :
- https://doi.org/10.1016/j.toxlet.2004.11.011