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Reusable Copper-Catalyzed Cross-Coupling Reactions of Aryl Halides with Organotins in Inexpensive Ionic Liquids.
- Source :
-
Journal of Organic Chemistry . 9/15/2006, Vol. 71 Issue 19, p7488-7490. 3p. 2 Charts. - Publication Year :
- 2006
-
Abstract
- A combination of Cu2O nanoparticles with P(o-tol)3 shows highly catalytic activity for the Stille cross-coupling reaction. A series of copper catalysts and ligands were evaluated, and Cu20 nanoparticles combined with P(o-tol)3 provided the best results. In the presence of Cu2O nanoparticles and P(o-tol)3, a variety of aryl halides including aryl chlorides underwent the Stille reaction with organotins smoothly in moderate to excellent yields using inexpensive TBAB (n-Bu4NBr) as the medium. It is noteworthy that the Cu2O/P(o-tol)3/TBAB system can be recovered and reused at least three times without any loss of catalytic activity among the reactions of aryl iodides and activated aryl bromides. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 71
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22517255
- Full Text :
- https://doi.org/10.1021/jo061220j