Controllable fabrication and characterization of biocompatible core-shell particles and hollow capsules as drug carrier

Abstract: SiO2@CdSe core-shell particles were fabricated by controllable deposition CdSe nanoparticles on silica colloidal spheres. Step-wise coating process was tracked by the TEM and XRD measurements. In addition, SiO2@CdSe/polypyrrole(PPy) multi-composite particles were synthesized based on the as-prepared SiO2@CdSe particles by cationic polymerization. The direct electrochemistry of myoglobin (Mb) could be performed by immobilizing Mb on the surface of SiO2@CdSe particles. Immobilized with Mb, SiO2@CdSe/PPy-Mb also displayed good bioelectrochemical activity. It confirmed the good biocompatible property of the materials with protein. CdSe hollow capsules were further obtained as the removal of the cores of SiO2@CdSe spheres. Hollow and porous character of CdSe sub-meter size capsules made them becoming hopeful candidates as drug carriers. Doxorubicin, a typical an antineoplastic drug, was introduced into the capsules. A good sustained drug release behavior of the loading capsules was discovered via performing a release test in the PBS buffer (pH 7.4) solution at 310k. Furthermore, SiO2@CdSe/PPy could be converted to various smart hollow capsules via selectively removal of their relevant components. [Copyright &y& Elsevier]