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A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
- Source :
-
Virology . Sep2006, Vol. 353 Issue 2, p268-282. 15p. - Publication Year :
- 2006
-
Abstract
- Abstract: HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wild-type (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes. [Copyright &y& Elsevier]
- Subjects :
- *HIV
*PREVENTIVE medicine
*VACCINATION
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Volume :
- 353
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 22592637
- Full Text :
- https://doi.org/10.1016/j.virol.2006.04.043