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Self-assembled, thermosensitive micelles of a star block copolymer based on PMMA and PNIPAAm for controlled drug delivery
- Source :
-
Biomaterials . Jan2007, Vol. 28 Issue 1, p99-107. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in water, which was confirmed by FT-IR, 1H NMR and fluorescence spectroscopy. Transmission electron microscopy images showed that these nanoparticles were regularly spherical in shape. The micelles showed reversible dispersion/aggregation in response to temperature cycles through an outer polymer shell lower critical solution temperature (LCST) for PNIPAAm at around 34°C, observed by optical absorbance measurements. Resulted polymeric micelles loaded with prednisone acetate showed a much improved drug release behavior due to the special micellar structure. [Copyright &y& Elsevier]
- Subjects :
- *POLYMERS
*METHYL methacrylate
*ELECTRON microscopy
*NANOPARTICLES
Subjects
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 28
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 22595051
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2006.08.030