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A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells
- Source :
-
Cancer Letters . Dec2006, Vol. 244 Issue 2, p247-251. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: An inhibitory-effect of a selective cyclooxygenase-2 (COX-2) inhibitor on peritoneal metastasis of scirrhous gastric carcinoma was investigated in vivo. Peritoneal metastasis had developed after intraperitoneal inoculation of scirrhous gastric cancer cells, OCUM-2MD3, in nude mice. COX-2 inhibitor and/or S-1 were administered orally in nude mice with peritoneal metastasis. Oral administration of COX-2 inhibitor and S-1 significantly prolonged survival rates of these nude mice, compared with either alone. These findings suggested that combining S-1 and COX-2 inhibitor administration obtain a synergistic inhibitory-effect on the peritoneal metastasis of scirrhous gastric carcinoma. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*CANCER invasiveness
*GASTRIC diseases
*PATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 244
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 22637439
- Full Text :
- https://doi.org/10.1016/j.canlet.2005.12.019