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Isoquinoline-1,3,4-trione and its derivatives attenuate β-amyloid-induced apoptosis of neuronal cells.
- Source :
-
FEBS Journal . Nov2006, Vol. 273 Issue 21, p4842-4852. 11p. 2 Color Photographs, 1 Diagram, 2 Charts, 5 Graphs. - Publication Year :
- 2006
-
Abstract
- Caspase-3 is a programmed cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. It is a promising therapeutic target for treatment of neurodegenerative diseases. We reported previously that isoquinoline-1,3,4-trione and its derivatives inhibit caspase-3. In this report, we validate isoquinoline-1,3,4-trione and its derivatives as potent, selective, irreversible, slow-binding and pan-caspase inhibitors. Furthermore, we show that these inhibitors attenuated apoptosis induced by β-amyloid(25–35) in PC12 cells and primary neuronal cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1742464X
- Volume :
- 273
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- FEBS Journal
- Publication Type :
- Academic Journal
- Accession number :
- 22740677
- Full Text :
- https://doi.org/10.1111/j.1742-4658.2006.05483.x