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Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2006, Vol. 16 Issue 23, p5963-5967. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these studies, we identified 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)borane (2g, AN0128) as having the best combination of anti-bacterial and anti-inflammatory activities. This compound is now in clinical development for dermatological conditions. [Copyright &y& Elsevier]
- Subjects :
- *SKIN inflammation
*ORGANIC compounds
*ANTI-infective agents
*SKIN diseases
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 23049339
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.08.130