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Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy
- Source :
-
Carbohydrate Research . Dec2006, Vol. 341 Issue 17, p2835-2841. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: In order to provide a suitable device that would contain water-soluble drugs, highly water-soluble gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres (CMS-Gd-DTPA) were prepared by the emulsion method using glutaraldehyde as a cross-linker and Span 80 as a surfactant for gadolinium neutron-capture therapy of cancer. The gadolinium content and the mass median diameter of CMS-Gd-DTPA were estimated. The size and morphology of the CMS-Gd-DTPA were strongly influenced by the initial applied weight ratio of Gd-DTPA:chitosan. FTIR spectra showed that the electrostatic interaction between chitosan and Gd-DTPA accelerated the formation of gadolinium-enriched chitosan microspheres. Sufficient amounts of glutaraldehyde and Span 80 were necessary for producing discrete CMS-Gd-DTPA. The CMS-Gd-DTPA having a mass median diameter 11.7μm and 11.6% of gadolinium could be used in Gd-NCT following intratumoral injection. [Copyright &y& Elsevier]
- Subjects :
- *DIETHYLENETRIAMINEPENTAACETIC acid
*FORAMINIFERA
*RHIZOPODA
*ALLOGROMIIDAE
Subjects
Details
- Language :
- English
- ISSN :
- 00086215
- Volume :
- 341
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Research
- Publication Type :
- Academic Journal
- Accession number :
- 23051239
- Full Text :
- https://doi.org/10.1016/j.carres.2006.09.016