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Rapid Systemic Bone Resorption during the Course of Staphylococcus aureus-Induced Arthritis.
- Source :
-
Journal of Infectious Diseases . 12/1/2006, Vol. 194 Issue 11, p1597-1600. 4p. - Publication Year :
- 2006
-
Abstract
- Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in non-infected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 194
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23082513
- Full Text :
- https://doi.org/10.1086/508751