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Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21Cip1/WAF1.
- Source :
-
American Journal of Physiology . Sep99 Part 2 of 2, Vol. 277 Issue 3, pH1100. 7p. 3 Black and White Photographs, 4 Graphs. - Publication Year :
- 1999
-
Abstract
- Investigates the molecular mechanisms involved in thrombospondin-1 (TSP-1)-mediated regulation of cell growth. Blockade of serum-inducible DNA synthesis in vascular smooth muscle cells after neutralizing A4.1 anti-TSP1 antibody; Essentiality of the p21 inhibitory protein for growth suppression on antibody blockade of TSP1.
- Subjects :
- *THROMBOSPONDINS
*CELL growth
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00029513
- Volume :
- 277
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 2324415