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103. IN VITRO SULFOXIDATION OF PHORATE AND METHIOCARB BY HUMAN P450 AND FMO ISOFORMS.

Source :
Drug Metabolism Reviews. 2002 Supplement 1, Vol. 34, p52-52. 1/2p.
Publication Year :
2002

Abstract

An abstract of the article "In Vitro Sulfoxidation of Phorate and Mithiocarb by Human P450 and FMO Isoforms" is presented. The study reveals that cytochrome P450 and flavin containing monooxygenases (FMO) are the primary enzyme systems responsible for catalyzing the oxidation of xenobiotics. It was found out that phorate metabolism to phorate sulfoxide and methiocarb metabolism to methiocarb sulfoxide by human liver were driven by P450 as compared to FMO.

Subjects

Subjects :
*OXIDATION
*FLAVINS
*MONOOXYGENASES
*SULFOXIDES

Details

Language :
English
ISSN :
03602532
Volume :
34
Database :
Academic Search Index
Journal :
Drug Metabolism Reviews
Publication Type :
Academic Journal
Accession number :
23256013

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