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Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation
- Source :
-
Trends in Cell Biology . Dec2006, Vol. 16 Issue 12, p607-609. 3p. - Publication Year :
- 2006
-
Abstract
- During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09628924
- Volume :
- 16
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Trends in Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 23280099
- Full Text :
- https://doi.org/10.1016/j.tcb.2006.10.004