Back to Search
Start Over
Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: Design, synthesis, and biological evaluation
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jan2007, Vol. 17 Issue 1, p278-281. 4p. - Publication Year :
- 2007
-
Abstract
- Abstract: A novel series of nitrogen-containing flavonoids 5a–l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors. The representative compounds 5a, 5b, 5e, and 5g showed potent CDK1/Cyclin B inhibitory activities. All compounds displayed a significant growth inhibitory action in vitro against Bel-7402, PC-3, ECA-109, A-549, HL-60, and MCF-7 cancer cell lines. Flow cytometry analysis showed that 5b induced apoptosis in PC-3 cells. [Copyright &y& Elsevier]
- Subjects :
- *FLAVONOIDS
*APOPTOSIS
*CYCLIN-dependent kinases
*CYTOMETRY
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 23514357
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.07.088