Back to Search
Start Over
Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti- Pythium activity.
- Source :
-
Environmental Microbiology . Feb2007, Vol. 9 Issue 2, p425-434. 10p. 3 Diagrams, 3 Graphs. - Publication Year :
- 2007
-
Abstract
- Under conditions of iron limitation Pseudomonas fluorescens ATCC 17400 produces two siderophores, pyoverdine, and a second siderophore quinolobactin, which itself results from the hydrolysis of the unstable molecule 8-hydroxy-4-methoxy-2-quinoline thiocarboxylic acid (thioquinolobactin). Pseudomonas fluorescens ATCC 17400 also displays a strong in vitro antagonism against the Oomycete Pythium, which is repressed by iron, suggesting the involvement of a siderophore(s). While a pyoverdine-negative mutant retains most of its antagonism, a thioquinolobactin-negative mutant only slowed-down Pythium growth, and a double pyoverdine-, thioquinolobactin-negative mutant, which does not produce any siderophore, totally lost its antagonism against Pythium. The siderophore thioquinolobactin could be purified and identified from spent medium and showed anti- Pythium activity, but it was quickly hydrolysed to quinolobactin, which we showed has no antimicrobial activity. Analysis of antagonism-affected transposon mutants revealed that genes involved in haem biosynthesis and sulfur assimilation are important for the production of thioquinolobactin and the expression of antagonism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14622912
- Volume :
- 9
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Environmental Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23626524
- Full Text :
- https://doi.org/10.1111/j.1462-2920.2006.01154.x