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L'énigme de l'entrée des lymphocytes T auto-immuns dans les tissus nerveux centraux et de leur attaque contre les structures de myéline
- Source :
-
Comptes Rendus Biologies . Jan2007, Vol. 330 Issue 1, p1-12. 12p. - Publication Year :
- 2007
-
Abstract
- Abstract: This paper describes the conditions under which autoimmune T cells enter the central nervous system to attack the local tissue. During a prodromal period preceding the onset of neurological disease, the CNS tissue is converted from its physiological immune-hostile state to an immune-friendly state. At the same time, in the peripheral immune system, activated autoimmune T cells undergo profound changes that allow them to enter through the blood-brain barrier and to finally interact with local autoantigen-presenting cells. Antigen recognition leads to T cell activation and the secretion of inflammatory mediators that are responsible for the development of the inflammatory lesions and the neurological deficits. To cite this article: H. Wekerle, C. R. Biologies 330 (2007). [Copyright &y& Elsevier]
- Subjects :
- *T cells
*CENTRAL nervous system
*IMMUNE system
*ANTIGENS
*INFLAMMATION
Subjects
Details
- Language :
- French
- ISSN :
- 16310691
- Volume :
- 330
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Comptes Rendus Biologies
- Publication Type :
- Academic Journal
- Accession number :
- 23741413
- Full Text :
- https://doi.org/10.1016/j.crvi.2006.10.002