QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography

Authors :: Wang, Sumin
Yang, Gengliang
Zhang, Hua
Liu, Haiyan
Li, Zhiwei
Source :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Feb2007, Vol. 846 Issue 1/2, p329-333. 5p.
Publication Year :: 2007
Abstract: Abstract: The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C18 stationary phase. Quantitative retention–activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD50) of cardiovascular system drugs was obtained. [Copyright &y& Elsevier]

Subjects :: *CHROMATOGRAPHIC analysis
*PHARMACOLOGY
*CARDIOVASCULAR agents
*HYDROGEN-ion concentration
*MICELLES
*DRUG toxicity

Language :: English
ISSN :: 15700232
Volume :: 846
Issue :: 1/2
Database :: Academic Search Index
Journal :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :: Academic Journal
Accession number :: 23808137
Full Text :: https://doi.org/10.1016/j.jchromb.2006.08.027

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