Clinical evaluation of pixellated NaI:Tl and continuous LaBr3:Ce, compact scintillation cameras for breast tumors imaging

Abstract: The principal limiting factor in the clinical acceptance of scintimammography is certainly its low sensitivity for cancers sized <1cm, mainly due to the lack of equipment specifically designed for breast imaging. The National Institute of Nuclear Physics (INFN) has been developing a new scintillation camera based on Lanthanum tri-Bromide Cerium-doped crystal (LaBr3:Ce), that demonstrating superior imaging performances with respect to the dedicated scintillation γ-camera that was previously developed. The proposed detector consists of continuous LaBr3:Ce scintillator crystal coupled to a Hamamatsu H8500 Flat Panel PMT. One centimeter thick crystal has been chosen to increase crystal detection efficiency. In this paper, we propose a comparison and evaluation between lanthanum γ-camera and a Multi PSPMT camera, NaI(Tl) discrete pixel based, previously developed under “IMI” Italian project for technological transfer of INFN. A phantom study has been developed to test both the cameras before introducing them in clinical trials. High resolution scans produced by LaBr3:Ce camera showed higher tumor contrast with a detailed imaging of uptake area than pixellated NaI(Tl) dedicated camera. Furthermore, with the lanthanum camera, the Signal-to-Noise Ratio (SNR) value was increased for a lesion as small as 5mm, with a consequent strong improvement in detectability. [Copyright &y& Elsevier]