Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Authors :: Letavic, Michael A.
Keith, John M.
Jablonowski, Jill A.
Stocking, Emily M.
Gomez, Leslie A.
Ly, Kiev S.
Miller, Jennifer M.
Barbier, Ann J.
Bonaventure, Pascal
Boggs, Jamin D.
Wilson, Sandy J.
Miller, Kirsten L.
Lord, Brian
McAllister, Heather M.
Tognarelli, D.J.
Wu, Jiejun
Abad, Marta C.
Schubert, Carsten
Lovenberg, Timothy W.
Carruthers, Nicholas I.
Source :: Bioorganic & Medicinal Chemistry Letters. Feb2007, Vol. 17 Issue 4, p1047-1051. 5p.
Publication Year :: 2007
Abstract: Abstract: A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed. [Copyright &y& Elsevier]

Subjects :: *QUINOLINE
*HISTAMINE
*SEROTONIN uptake inhibitors
*PHARMACOKINETICS

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