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One-pot synthesis of polysubstituted pyridine derivatives using ketene dithioacetals
- Source :
-
Tetrahedron . Mar2007, Vol. 63 Issue 11, p2511-2518. 8p. - Publication Year :
- 2007
-
Abstract
- Abstract: Polysubstituted pyridine derivatives were synthesized by the reaction of ketene dithioacetal, 3,3-bis(methylsulfanyl)methylenemalononitrile 1b, with a variety of active methylene compounds in the presence of either sodium hydroxide or potassium hydroxide as a base in DMSO. This reaction was carried out under economical one-pot reaction conditions (cheap catalyst and solvent) and solved the problem of the odor of methanethiol, commonly derived from reactions of ketene dithioacetals. This is a significant enhancement of GSC (green and sustainable chemistry) in the field of ketene dithioacetal chemistry. [Copyright &y& Elsevier]
- Subjects :
- *BIOSYNTHESIS
*PYRIDINE derivatives
*KETENES
*HETEROCYCLIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 63
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 23947022
- Full Text :
- https://doi.org/10.1016/j.tet.2006.12.031