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Evaluation of renal tubular function in children taking anti-epileptic treatment.
Evaluation of renal tubular function in children taking anti-epileptic treatment.
- Source :
-
Nephrology . Dec2006, Vol. 11 Issue 6, p485-488. 4p. 2 Charts, 3 Graphs. - Publication Year :
- 2006
-
Abstract
- Aim: To assess the effects of anti-epileptic drugs on renal tubular function. Methods: Urinary N-acetyl-β-D-glucosaminidase activity was measured in 114 epileptic children (mean age 5.6 ± 1.1 years) who were undergoing monotherapy with valproate ( n = 46), carbamazepine ( n = 34), lamotrigine ( n = 13) and combined therapy with valproate+carbamazepine ( n = 21). Results: The urinary N-acetyl-β-D-glucosaminidase index of valproate ( P < 0.01), carbamazepine ( P < 0.05) and polytherapy group ( P < 0.01) were significantly elevated when compared with that of the control group. No significant difference in N-acetyl-β-D-glucosaminidase levels was found between the lamotrigine group and the control subjects. We found that the distribution of the N-acetyl-β-D-glucosaminidase values of patients depended significantly on the length of therapy ( P < 0.01). The level of urinary excretion of N-acetyl-β-D-glucosaminidase was significantly higher in the patients who were taking long-term treatment (>10 years) with valproate, carbamazepine and combined therapy than those taking therapy shorter than 10 years ( P < 0.01). The mean serum concentrations of valproate and carbamazepine were 68.7 ± 17.44 µg/mL and 5.41 ± 1.23 µg/mL, respectively. There was a significant correlation between the serum concentration of valproate and urinary N-acetyl-β-D-glucosaminidase levels ( r = 0.44, P < 0.01). There was also a significant correlation between the serum concentration of carbamazepine and N-acetyl-β-D-glucosaminidase excretion ( r = 0.52, P < 0.01). Conclusion: The present study demonstrated that in patients treated with valproate and carbamazepine, an impairment of tubular function can be present, whereas lamotrigine does not cause any significant change. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13205358
- Volume :
- 11
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 24025277
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2006.00699.x