Back to Search
Start Over
Synthesis and SAR of 3,5-diamino-piperidine derivatives: Novel antibacterial translation inhibitors as aminoglycoside mimetics
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2007, Vol. 17 Issue 5, p1206-1210. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth. [Copyright &y& Elsevier]
- Subjects :
- *ANTI-infective agents
*AMINOGLYCOSIDES
*NUCLEIC acids
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 24046188
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.12.024