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Synthesis and anticancer activity of a novel class of flavonoids: 2,4-Diarylchromane[4,3-d]-Δ1,9b-1,2,3-thiadiazolines
- Source :
-
European Journal of Medicinal Chemistry . Feb2007, Vol. 42 Issue 2, p226-234. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: A series of 2,4-diarylchromane[4,3-d]-Δ1,9b-1,2,3-thiadiazolines have been synthesized by cyclization of corresponding 2-arylchroman-4-one-arylhydrazones with SOCl2 then treated with alcohol. All the compounds have been tested for their antiproliferative activity in vitro against six human tumor cell lines, and the highly potent derivative 11a exhibited in vivo inhibitory effect on tumor growth. Mechanism research indicated that it is due to 11a that induces DNA fragmentation. [Copyright &y& Elsevier]
- Subjects :
- *ANTINEOPLASTIC agents
*FLAVONOIDS
*RING formation (Chemistry)
*CANCER cells
*DNA
Subjects
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24137992
- Full Text :
- https://doi.org/10.1016/j.ejmech.2006.10.004