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Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase
- Source :
-
Cell Biology International . Mar2007, Vol. 31 Issue 3, p257-262. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation. [Copyright &y& Elsevier]
- Subjects :
- *CELLS
*IMMUNOREGULATION
*CELL proliferation
*DISEASES
Subjects
Details
- Language :
- English
- ISSN :
- 10656995
- Volume :
- 31
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cell Biology International
- Publication Type :
- Academic Journal
- Accession number :
- 24148817
- Full Text :
- https://doi.org/10.1016/j.cellbi.2006.11.002