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Stability and Hopf bifurcation in an approachable haematopoietic stem cells model
- Source :
-
Mathematical Biosciences . Apr2007, Vol. 206 Issue 2, p176-184. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: We consider the haematopoietic stem cells model (HSC) with one delay introduced by Mackey [M.C. Mackey, Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis, blood 51 (1978) 5; M.C. Mackey, Mathematical models of haematopoietic cell replication and control, in: The Art of Mathematical Modelling: Case Studies in Ecology, Physiology and Biofluids, H.G. Othmer, F.R. Adler, M.A. Lewis, J.C. Dallon (Eds), Prentice-Hall, New York, 1997, p. 149] and Andersen and Mackey [L.K. Andersen, M.C. Mackey, Resonance in periodic chemotherapy: a case study of acute myelogenous leukemia, J. theor. Biol. 209 (2001) 113]. There are two possible stationary states in the model. One of them is trivial and the second E ∗(τ) depending on the delay is non-trivial . This paper investigates the stability of the non-trivial state and occurrence of the Hopf bifurcation depending on time delay. We prove the existence and uniqueness of a critical values τ 0 and of the delay such that E ∗(τ) is asymptotically stable for τ < τ 0 and unstable for . We show that E ∗(τ 0) is a Hopf bifurcation critical point for an approachable model. [Copyright &y& Elsevier]
- Subjects :
- *STEM cells
*APLASTIC anemia
*MYELOID leukemia
*ANEMIA
Subjects
Details
- Language :
- English
- ISSN :
- 00255564
- Volume :
- 206
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Mathematical Biosciences
- Publication Type :
- Periodical
- Accession number :
- 24547625
- Full Text :
- https://doi.org/10.1016/j.mbs.2006.03.004