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Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.

Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.

Authors :
Kyrtsonis, Marie-Christine
Vassilakopoulos, Theodoros P.
Kafasi, Nicoletta
Sachanas, Sotirios
Tzenou, Tatiana
Papadogiannis, Argiroula
Galanis, Zacharoula
Kalpadakis, Christina
Dimou, Maria
Kyriakou, Elias
Angelopoulou, Maria K.
Dimopoulou, Maria N.
Siakantaris, Marina P.
Dimitriadou, Evangelia M.
Kokoris, Styliani I.
Panayiotidis, Panayiotis
Pangalis, Gerassimos A.
Source :
British Journal of Haematology. May2007, Vol. 137 Issue 3, p240-243. 4p. 1 Chart, 1 Graph.
Publication Year :
2007

Abstract

The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as κ/ λ or λ/ κ, depending on the patients’ dominating monoclonal light chain. Median baseline sFLCR was 3·57 in κ-MM patients, 45·09 in λ-MM. ‘High’ sFLCR (≥ the observed median value for κ- and λ-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively ( P = 0·0001). sFLCR was an independent prognostic factor. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00071048
Volume :
137
Issue :
3
Database :
Academic Search Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
24594178
Full Text :
https://doi.org/10.1111/j.1365-2141.2007.06561.x