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Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.
Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.
- Source :
-
British Journal of Haematology . May2007, Vol. 137 Issue 3, p240-243. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2007
-
Abstract
- The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as κ/ λ or λ/ κ, depending on the patients’ dominating monoclonal light chain. Median baseline sFLCR was 3·57 in κ-MM patients, 45·09 in λ-MM. ‘High’ sFLCR (≥ the observed median value for κ- and λ-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively ( P = 0·0001). sFLCR was an independent prognostic factor. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 137
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 24594178
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2007.06561.x