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Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii
- Source :
-
Phytochemistry . Apr2007, Vol. 68 Issue 8, p1172-1178. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract: The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide. [Copyright &y& Elsevier]
- Subjects :
- *TETRAHYDROFURAN
*IMMUNOREGULATION
*DNA polymerases
*POLYMERASE chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 68
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24616465
- Full Text :
- https://doi.org/10.1016/j.phytochem.2007.02.021