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Seamless Method Transfer from UPLC Technology to Preparative LC.

Authors :
Fang Xia
Cavanaugh, Jie V.
Diehl, Diane M.
Wheat, Thomas E.
Mazzeo, Jeffrey R.
Source :
LC-GC Europe. Mar2007 Applications Book, Vol. 20, p47-48. 2p.
Publication Year :
2007

Abstract

The article offers information on how to scale the UltraPerformance liquid chromatography (UPLC) impurity/degradant separation to a preparative LC separation. The UPLC separation of the ranitidine degradation sample succeeds because it was found that ranitidine is resolved from all other compounds in the mixture. Moreover, further optimization can be achieved by simple modification of the gradient profile.

Details

Language :
English
ISSN :
14716577
Volume :
20
Database :
Academic Search Index
Journal :
LC-GC Europe
Publication Type :
Academic Journal
Accession number :
24632110