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Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring.
- Source :
-
FASEB Journal . Apr2007, Vol. 21 Issue 4, p1264-1270. 7p. 5 Graphs. - Publication Year :
- 2007
-
Abstract
- The treatment of dyspeptic disorders with anti-acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30-50% of pregnant women due to reflux and heart-burn, we aimed here to investigate the impact of maternal therapy with anti-acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti-acid drug, to pregnant BALB/c mice during pregnancy and lactation. These mothers developed a codfish-specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensitization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these offspring we found a relative Th2-dominance, because the Th1- and T-regulatory cytokines were significantly suppressed. Our data provide evidence that the anti-acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2-milieu in their offspring. From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACIDS
*PREGNANT women
*ALLERGENS
*IMMUNE response
*LACTATION
Subjects
Details
- Language :
- English
- ISSN :
- 08926638
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- FASEB Journal
- Publication Type :
- Academic Journal
- Accession number :
- 24810453
- Full Text :
- https://doi.org/10.1096/fj.06-7223com