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Melanoma-Associated Antigen Family Protein-D1 Regulation of Tumor Cell Migration, Adhesion to Endothelium, and Actin Structures Reorganization in Response to Hypoxic Stress.
- Source :
-
Cell Communication & Adhesion . Jan/Feb2007, Vol. 14 Issue 1, p21-31. 11p. 7 Graphs. - Publication Year :
- 2007
-
Abstract
- Melanoma-associated antigen family protein-D1 (MAGE-D1) is a recently identified p75 neurotrophin receptor intracellular binding protein and functions as an adaptor that mediates multiple signaling pathways, including Dlx/Msx-mediated transcription. Here, a new regulatory function for MAGE-D1 in tumor cell motility and adhesion to endothelium is described. MAGE-D1 over-expression suppressed HeLa cell and BEL7402 cell migration, invasion, and adhesion to the monolayer of ECV304 cells. We also report that MAGE-D1 over-expression disrupted actin cytoskeleton rearrangement induced by hypoxia and down-regulated hypoxia inducible factor 1-dependent luciferase gene expression. These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15419061
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cell Communication & Adhesion
- Publication Type :
- Academic Journal
- Accession number :
- 24827195
- Full Text :
- https://doi.org/10.1080/15419060701224948