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Pacing-Induced Dyssynchrony During Early Reperfusion Reduces Infarct Size
- Source :
-
Journal of the American College of Cardiology (JACC) . May2007, Vol. 49 Issue 17, p1813-1819. 7p. - Publication Year :
- 2007
-
Abstract
- Objectives: Considering the recent discovery of postconditioning, we investigated whether intermittent dyssynchrony immediately upon reperfusion induces cardioprotection as well. Background: Intermittent dyssynchrony, induced by ventricular pacing, preconditions myocardium. Methods: Isolated ejecting rabbit hearts were subjected to 30-min coronary occlusion and 2-h reperfusion. Control, left ventricular (LV) pacing preconditioning (LVPpreC) (3 × 5-min LV pacing), and LV pacing postconditioning (LVPpostC) (10 × 30-s LV pacing during early reperfusion) groups were studied. Mechanical effects of LV pacing were determined using local pressure-length loops (sonomicrometry), whereas effects on myocardial lactate release and coronary flow were assessed from coronary effluent and fluorescent microspheres, respectively. Anesthetized pigs underwent 60-min coronary occlusion and 3-h reperfusion in control and right ventricular (RV) pacing postconditioning groups (RVPpostC) (10 × 30-s RV pacing during early reperfusion). In all hearts, area at risk and infarct size were determined with blue dye and triphenyltetrazolium chloride staining, respectively. Results: Infarct size, normalized to area at risk, was 47.0 ± 12.3% in control rabbit hearts, but significantly smaller in LVPpreC (17.8 ± 6.4%) and LVPpostC hearts (17.9 ± 4.4%). Left ventricular pacing significantly altered regional mechanical work, but did not affect coronary flow or lactate release. In pigs, infarct size was significantly smaller in RVPpostC (9.8 ± 3.0%) than in control (20.6 ± 2.2%) animals. Conclusions: Intermittent dyssynchrony during early reperfusion reduces infarct size in 2 different animal models. Dyssynchrony-induced postconditioning cannot be attributed to graded reperfusion but may be induced by modulation of local myocardial workload. Dyssynchrony-induced postconditioning opens new possibilities for cardioprotection in the clinical setting. [Copyright &y& Elsevier]
- Subjects :
- *CORONARY arteries
*HEART blood-vessels
*VASCULAR surgery
*PLASTIC surgery
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 49
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 24864235
- Full Text :
- https://doi.org/10.1016/j.jacc.2007.01.070