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PD-1 and its ligands in T-cell immunity
- Source :
-
Current Opinion in Immunology . Jun2007, Vol. 19 Issue 3, p309-314. 6p. - Publication Year :
- 2007
-
Abstract
- The past year has seen significant advances in our understanding of the critical roles of negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 ligand (PD-L) pathway in regulating T-cell activation and tolerance. Emerging evidence indicates that PD-Ls play an essential role on dendritic cells (DCs), both directly during DC–T cell interactions and indirectly through signaling into the DC. Recent studies point to a novel role for PD-L1 in maintaining tissue tolerance. Finally, PD-1 has recently been shown to be highly expressed on exhausted T cells during chronic viral infection, and blockade of PD-1 or PD-L1 can revive exhausted T cells, enabling them to proliferate and produce effector cytokines. [Copyright &y& Elsevier]
- Subjects :
- *CELLULAR control mechanisms
*DENDRITIC cells
*CELL communication
*IMMUNOREGULATION
Subjects
Details
- Language :
- English
- ISSN :
- 09527915
- Volume :
- 19
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25033123
- Full Text :
- https://doi.org/10.1016/j.coi.2007.04.012