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A systematic bioinformatics approach for selection of epitope-based vaccine targets
- Source :
-
Cellular Immunology . Dec2006, Vol. 244 Issue 2, p141-147. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: Epitope-based vaccines provide a new strategy for prophylactic and therapeutic application of pathogen-specific immunity. A critical requirement of this strategy is the identification and selection of T-cell epitopes that act as vaccine targets. This study describes current methodologies for the selection process, with dengue virus as a model system. A combination of publicly available bioinformatics algorithms and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human leukocyte antigen (HLA) alleles. The selected sequences are tested for biological function by their activation of T-cells of HLA transgenic mice and of pathogen infected subjects. This approach provides an experimental basis for the design of pathogen specific, T-cell epitope-based vaccines that are targeted to majority of the genetic variants of the pathogen, and are effective for a broad range of differences in human leukocyte antigens among the global human population. [Copyright &y& Elsevier]
- Subjects :
- *PREVENTIVE medicine
*BIOINFORMATICS
*COMPUTERS in medicine
*IMMUNE system
Subjects
Details
- Language :
- English
- ISSN :
- 00088749
- Volume :
- 244
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cellular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25098118
- Full Text :
- https://doi.org/10.1016/j.cellimm.2007.02.005