Back to Search
Start Over
Genome Sequence Diversity and Clues to the Evolution of Variola (Smallpox) Virus.
- Source :
-
Science . 8/11/2006, Vol. 313 Issue 5788, p807-812. 6p. - Publication Year :
- 2006
-
Abstract
- Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral virulence differences. Analysis of the viral linear DNA genome suggests that its evolution involved direct descent and DNA end-region recombination events. Knowing the sequences will help understand the viral proteome and improve diagnostic test precision, therapeutics, and systems for their assessment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 313
- Issue :
- 5788
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 25117643
- Full Text :
- https://doi.org/10.1126/science.1125134