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Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression
- Source :
-
Biochemical & Biophysical Research Communications . Jul2007, Vol. 358 Issue 3, p925-930. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Twist, a newly found EMT-inducer, has been reported to be up-regulated in those of diffuse-type gastric carcinomas with high N-cadherin level. We show here MKN45, a cell line derived from undifferentiated carcinomas cells, expresses high levels of Twist. Down-regulation of Twist, using an antisense Twist vector in MKN45 cells, inhibits cell migration and invasion, companied with a morphologic changes associated with MET. Suppression of Twist also decreases the expressions of N-cadherin and fibronectin, but not of E-cadherin in MKN45. In contrast, overexpression of Twist in MKN28, a cell line derived from moderate differentiated carcinomas, results in up-regulation of N-cadherin and fibronectin, companied with down-regulation of E-cadherin. Taken together, our results suggest that Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*CELL lines
*CELL migration
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 358
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 25182582
- Full Text :
- https://doi.org/10.1016/j.bbrc.2007.05.023