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Hepatitis B virus (HBV) genotypes/subgenotypes in China: Mutations in core promoter and precore/core and their clinical implications
- Source :
-
Journal of Clinical Virology . Jun2007, Vol. 39 Issue 2, p87-93. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract: Background: The association of hepatitis B virus (HBV) genotypes with clinical course of infection is increasingly recognized. Objectives: In order to investigate the genetic diversity of HBV and its clinical implications, 241 HBV-infected patients including 34 with hepatocellular carcinoma (HCC) were enrolled in this study. Methods: HBV genotyping was performed with an ELISA assay. HBV subgenotypes were determined by PCR-RFLP. HBV core promoter/precore/core mutations were analyzed by direct sequencing. Results: The overall prevalence of HBV/B and C was 65% and 33%, respectively. Among HBV/C, 42% were Cs/C1 and 58% were Ce/C2. The HBV/C1 was only found in the patients originating from Southern China (p =0.0001). Among HCC patients, HBV/C2 was only found in the elder age group (≥51 years; p <0.05) and HBV/Ba was associated with young HCC patients (<35 years). Mutations associated with HCC were V1753 and T1762/A1764 (p <0.01). The prevalence of the V1753 was higher in HBV/C1 strains (p <0.04), A1898 was only found among HBV/C1 (p =0.056). T1762/A1764 was frequently demonstrated in both subgenotypes. The T1858 (90%) and A1896 (40%) mutations were most frequent in HBV/C2 (p <0.008). Conclusions: HBV/C1 and HBV/C2 have distinct geographic distributions in China. V1753 in addition to T1762/A1764 double mutation in the basal core promoter region seems to be associated with HCC development, especially in the patients with HBV/C1. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 13866532
- Volume :
- 39
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 25190081
- Full Text :
- https://doi.org/10.1016/j.jcv.2007.03.005