The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Authors :: Taylor, Warren D.
Züchner, Stephan
Payne, Martha E.
Messer, Denise F.
Doty, Tracy J.
MacFall, James R.
Beyer, John L.
Krishnan, K. Ranga R.
Source :: Psychiatry Research: Neuroimaging. Jul2007, Vol. 155 Issue 2, p173-177. 5p.
Publication Year :: 2007
Abstract: Abstract: We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes. [Copyright &y& Elsevier]