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Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
- Source :
-
Neuron . Jun2007, Vol. 54 Issue 5, p801-812. 12p. - Publication Year :
- 2007
-
Abstract
- Summary: Endocannabinoids (eCBs) have emerged as key activity-dependent signals that, by activating presynaptic cannabinoid receptors (i.e., CB1) coupled to Gi/o protein, can mediate short-term and long-term synaptic depression (LTD). While the presynaptic mechanisms underlying eCB-dependent short-term depression have been identified, the molecular events linking CB1 receptors to LTD are unknown. Here we show in the hippocampus that long-term, but not short-term, eCB-dependent depression of inhibitory transmission requires presynaptic cAMP/PKA signaling. We further identify the active zone protein RIM1α as a key mediator of both CB1 receptor effects on the release machinery and eCB-dependent LTD in the hippocampus. Moreover, we show that eCB-dependent LTD in the amygdala and hippocampus shares major mechanistic features. These findings reveal the signaling pathway by which CB1 receptors mediate long-term effects of eCBs in two crucial brain structures. Furthermore, our results highlight a conserved mechanism of presynaptic plasticity in the brain. [Copyright &y& Elsevier]
- Subjects :
- *CANNABINOIDS
*PROTEINS
*HIPPOCAMPUS (Brain)
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Volume :
- 54
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 25320055
- Full Text :
- https://doi.org/10.1016/j.neuron.2007.05.020