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Highly potent growth hormone secretagogues
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2007, Vol. 17 Issue 13, p3657-3659. 3p. - Publication Year :
- 2007
-
Abstract
- Abstract: During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H. L.; Hickey, G. J.; Smith, R. G.; Patchett, A. A. Bioorg. Med. Chem. Lett. 1997, 7, 2319.]. Animal studies show that compound 8 can stimulate growth hormone release at the oral dose as low as 0.06mpk. Chemistry and biological studies are discussed. [Copyright &y& Elsevier]
- Subjects :
- *HORMONES
*ORGANIC compounds
*HUMAN anatomy
*ENDOCRINE glands
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 25410218
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.04.050